Create a sweetener Risk Associated with Diabetes and Obesity

Sweetener that is used in the history of honey, which is used in Greek and Chinese culture. Along with time, replaced with sakarosa honey, produced from sugar cane.

The first artificial sweetener is saccharin produced, which was first created by Remsen and Fahlberg in 1879. Saccharin is widely accepted in the period to World War I and II, because the relative cost of production cheaper and less sugar reserves at that time.

After the world war, economic ability of the community began to recover, and the sugar starts again widely available. However, the growth of production of sugar candy and food industry fast food, increasing numbers Obesity incidence in the community. Because of that, for reasons Feed reduce calories and lower the incidence Obesity, artificial sweetener is used more and more sugar than usual. Because profitable, the market continues with dibanjiri products penurun calories, so that the use of artificial sweetener has been increasing.

But whether true artificial sweetener can reduce calorie Feed number and lower incidence Obesity and diabetes even melitus?
In the meeting of The Endocrine Society to-91, Endo 2009, presented a study that reported that people who consume artificial sweetener easier melitus suffering diabetes and is easier to insulin resistance compared with people who do not use artificial sweetener.


Kristofer S. Gravenstein is a main researcher of this study, in collaboration with the Clinical Research Branch of the National Institute of Aging (NIA), National Institutes of Health (NIH). This study analyzes data from 1257 participants were involved in the Baltimore longitudinal Study of Aging (BLSA, a research that started in 1958), with the Average age of 64.8 years (range, 21-96 years). Patients have personal data on a daily Feed, TTGO (oral glucose tolerance test) and also measurements antropometrik. Research is divided into 3 research groups: artificial sweetener users, not the artificial sweetener users, and control. Artificial sweetener that is most widely used aspartam (most preferred by 66% participants BLSA), saccharin (13%), sukralosa (1.0%), and a combination of three (21%).

Gravenstein said that at the time of the analysis is done, the experts found that research participants consume more fat before 1983. Year 1983 was a year where it was increasing the use of artificial sweetener in the United States. That year is also the year in which approval as aspartam artificial sweetener and diet Coke in the community began to be introduced. Therefore, further analysis carried out on data from patients in 1983.

Results of analysis showed that when compared with the 550 participants who do not use artificial sweetener, 443 participants aged artificial sweetener users younger, had a body weight and body mass index have a greater, although they do not consume more calories than those who do not use the sweetener made. Feed fat, carbohydrate, protein and total calorie Feed not differ between the artificial sweetener users with non users.

Gravenstein also said that in this research, the opportunity for users to have the artificial sweetener TTGO or degree of normal glucose homeostasis is smaller than the non-users. In addition, with respect to the status of glucose, the TGT (disturbed glucose tolerance) and / or GPT (subject fasting glucose), users have the artificial sweetener of a diabetes prevalence of the same patients with prediabetes. Participants who use the artificial sweetener has a 2-fold risk of more affected by diabetes (8.8%), compared with control (4.4%).

On further analysis on subpopulasi, experts compare the fasting insulin level among 374 non-users with 311 users artificial sweetener. Artificial sweetener appeared to have the user measure fasting blood glucose is higher, fasting insulin level is higher and the insulin resistance is greater. Measure HbA1c (glycosylated hemoglobin A1C) was not different between the two research groups.

Experts conclude a hypothesis that the artificial sweetener effect on body metabolism, cell endokrin through enteral, and therefore contribute to the occurrence of diabetes and / or Obesity. However, this hypothesis memerlukkan research further with the analysis of longitudinal research and intervention.